MIDD(Model-informed Drug Development)

Good Practices in Model-Informed Drug Discovery and Development
Marshall et al.
Drug development and model building
Learning and confirming

빟룞빟젰븰 紐⑤뜽留곸쓣 룷븿븳 떎뼇븳 紐⑤뜽留-떆裕щ젅씠뀡 湲곕쾿뱾 씠誘 삤옒 쟾遺꽣 떊빟 媛쒕컻뿉 쟻슜릺뼱 솕뒿땲떎.
洹 슚슜꽦씠 엯利앸릺硫댁꽌 씠젣뒗 쟾泥댁쟻씤 떊빟 媛쒕컻쓽 쟾왂 肉먮쭔 븘땲씪 떊빟 諛쒓뎬 떒怨꾩뿉源뚯룄 솢슜릺뒗 異붿꽭엯땲떎. 씠뒗 誘멸뎅 FDA 벑 洹쒖젣 湲곌뱾룄 씠윭븳 듃젋뱶瑜 쟻洹 吏吏븯怨 엳쑝硫, 떊빟 媛쒕컻 pipeline쓽 利앷뿉 뵲씪 援궡뿉룄 븘닔쟻쑝濡 슂援щ릺뒗 湲곗닠濡 옄由ъ옟븯뒿땲떎.

PIPET 援궡 MIDD 솢꽦솕瑜 쐞븳 떊湲곗닠 룄엯 諛 쟾臾멸 뼇꽦 벑 떎뼇븳 솢룞쓣 닔뻾븯怨 엳뒿땲떎.
湲곗〈쓽 샎빀슚怨 紐⑤뜽留곸쓣 넻븳 빟룞빟젰븰 遺꾩꽍쓣 꽆뼱 떎젣 떊빟 媛쒕컻 봽濡쒖젥듃뿉 븳 깮由ы븰쟻湲곕컲 빟룞븰(PBPK) 紐⑤뜽留, 떆뒪뀥빟由ы븰(Systems pharmacology) 紐⑤뜽留 벑쓽 쟻슜 諛⑹븞쓣 뿰援ы빐 솕쑝硫, 씠뿉 뵲씪 媛 봽濡쒖젥듃쓽 듅꽦 蹂꾨줈 留욎땄삎 紐⑤뜽留-떆裕щ젅씠뀡 쟾왂쓣 젣븞븯怨, 理쒖쟻쓽 쓽궗 寃곗젙 洹쇨굅瑜 젣떆븷 닔 엳뒗 쟾臾몄꽦쓣 솗蹂댄븯뒿땲떎.

슦由ъ쓽 뿰援 꽦怨 以 怨좊룄솕, 젙삎솕맂 쁺뿭 Q-fitter(www.q-fitter.com)瑜 넻빐 젣빟궗 諛 諛붿씠삤뀓 벑 떊빟 媛쒕컻 二쇱껜뱾쓣 긽쑝濡 븯뒗 긽슜 꽌鍮꾩뒪濡쒖꽌 젣怨듬릺怨 엳쑝硫, PIPET 씠윭븳 꽌鍮꾩뒪쓽 쟻슜 踰붿쐞 솗, 泥⑤떒 湲곗닠 젒紐 벑쓣 쐞빐 吏냽쟻씤 뿰援 솢룞쓣 씠뼱媛怨 엳뒿땲떎.