A NONMEM 실행결과
14장 NONMEM의 $COVARIANCE의 14.1에서 언급된 NONMEM 실행결과를 별첨으로 수록하였다. 지면 관계상 작은 글자 크기로 수록되었으나 웹9에서 동일한 내용을 확인할 수 있다.
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******************** FIRST ORDER ***
******************** STANDARD ERROR OF ESTIMATE ***
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THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3
6.41E-01 1.68E+00 2.31E-02
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3
ETA1 4.21E-01
ETA2 8.22E-02 1.98E-02
ETA3 3.40E-01 2.30E-02 2.89E-01
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1 EPS2
EPS1 3.58E-03
EPS2 ......... 3.21E-02
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3
ETA1 1.92E-01
ETA2 1.78E-01 5.59E-02
ETA3 2.10E-01 1.99E-01 2.89E-01
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1 EPS2
EPS1 1.63E-02
EPS2 ......... 6.88E-02
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******************** FIRST ORDER ***
******************** COVARIANCE MATRIX OF ESTIMATE ***
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TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 4.11E-01
TH 2 3.39E-01 2.84E+00
TH 3 5.75E-03 5.04E-03 5.32E-04
OM11 2.06E-01 3.37E-01 1.63E-03 1.77E-01
OM12 2.01E-03 3.48E-02 -1.04E-03 1.95E-02 6.75E-03
OM13 1.22E-01 1.49E-01 7.11E-03 5.75E-02 -1.01E-02 1.16E-01
OM22 -2.19E-03 1.28E-02 -2.50E-04 3.21E-03 1.50E-03 -2.83E-03 3.92E-04
OM23 1.00E-03 2.38E-02 6.31E-05 4.21E-03 8.56E-04 3.12E-03 2.32E-04 5.31E-04
OM33 6.70E-02 5.74E-02 6.22E-03 1.80E-02 -1.31E-02 9.40E-02 -3.27E-03 1.87E-03 8.38E-02
SG11 1.05E-03 1.81E-03 5.81E-05 5.14E-04 -7.52E-05 9.77E-04 -2.05E-05 2.79E-05 8.05E-04 1.28E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -4.97E-03 -9.95E-03 -4.79E-04 -1.01E-03 9.53E-04 -3.86E-03 1.81E-04 2.20E-04 -3.40E-03 -2.82E
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******************** FIRST ORDER ***
******************** CORRELATION MATRIX OF ESTIMATE ***
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TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 6.41E-01
TH 2 3.14E-01 1.68E+00
TH 3 3.89E-01 1.30E-01 2.31E-02
OM11 7.63E-01 4.76E-01 1.68E-01 4.21E-01
OM12 3.81E-02 2.52E-01 -5.49E-01 5.64E-01 8.22E-02
OM13 5.57E-01 2.60E-01 9.06E-01 4.02E-01 -3.61E-01 3.40E-01
OM22 -1.73E-01 3.83E-01 -5.48E-01 3.85E-01 9.24E-01 -4.19E-01 1.98E-02
OM23 6.79E-02 6.14E-01 1.19E-01 4.35E-01 4.52E-01 3.98E-01 5.09E-01 2.30E-02
OM33 3.61E-01 1.18E-01 9.32E-01 1.48E-01 -5.50E-01 9.54E-01 -5.70E-01 2.80E-01 2.89E-01
SG11 4.58E-01 3.00E-01 7.04E-01 3.42E-01 -2.56E-01 8.02E-01 -2.90E-01 3.38E-01 7.78E-01 3.58E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -2.42E-01 -1.84E-01 -6.47E-01 -7.52E-02 3.61E-01 -3.54E-01 2.84E-01 2.97E-01 -3.66E-01 -2.46E
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******************** FIRST ORDER ***
******************** INVERSE COVARIANCE MATRIX OF ESTIMATE ***
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TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 1.06E+02
TH 2 -6.86E+01 5.80E+01
TH 3 6.45E+03 -4.88E+03 5.90E+05
OM11 3.36E+02 -3.02E+02 2.70E+04 1.68E+03
OM12 -2.55E+03 2.18E+03 -1.89E+05 -1.17E+04 8.48E+04
OM13 -1.20E+03 9.40E+02 -9.03E+04 -5.09E+03 3.58E+04 1.67E+04
OM22 -3.88E+02 5.71E+02 -6.62E+04 -3.41E+03 1.37E+04 1.09E+04 7.22E+04
OM23 1.08E+04 -8.98E+03 7.96E+05 4.74E+04 -3.37E+05 -1.50E+05 -1.17E+05 1.42E+06
OM33 -4.97E+01 8.80E+01 -1.06E+04 -4.44E+02 3.32E+03 9.71E+02 2.83E+03 -1.41E+04 9.57E+02
SG11 1.17E+04 -1.01E+04 8.99E+05 5.33E+04 -3.79E+05 -1.67E+05 -1.39E+05 1.59E+06 -2.01E+04 2.03E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -1.04E+03 1.00E+03 -4.72E+04 -4.88E+03 3.51E+04 1.43E+04 1.57E+04 -1.52E+05 9.39E+02 -1.70E
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******************** FIRST ORDER ***
******************** EIGENVALUES OF COR MATRIX OF ESTIMATE ***
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1 2 3 4 5 6 7 8 9 10
2.52E-04 9.67E-03 1.08E-02 2.33E-02 5.21E-02 2.98E-01 5.05E-01 9.11E-01 1.21E+00 3.21E
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******************** FIRST ORDER ***
******************** R MATRIX ***
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TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 1.79E+01
TH 2 -1.33E+00 5.51E-01
TH 3 -1.63E+02 -7.67E+00 3.43E+04
OM11 -4.13E+00 1.12E-01 8.60E+01 2.86E+01
OM12 2.16E+01 -1.46E+00 4.34E+02 -1.77E+02 1.93E+03
OM13 -1.10E+01 2.99E+00 -9.08E+01 -5.29E+01 2.11E+02 2.13E+02
OM22 1.02E+01 -1.65E+01 1.35E+01 2.73E+02 -4.27E+03 -1.40E+02 1.66E+04
OM23 5.23E+01 -1.83E+01 9.57E+02 1.64E+02 -1.42E+03 -5.56E+02 1.11E+03 4.05E+03
OM33 7.05E+00 -2.23E+00 -1.35E+03 2.45E+01 -4.37E+01 -1.51E+02 1.87E+01 1.31E+02 2.37E+02
SG11 2.49E+02 -1.21E+02 -7.03E+03 5.03E+01 -1.01E+03 9.63E+01 4.68E+03 -5.57E+02 -2.03E+01 1.93E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 -1.75E+00 -5.21E+00 -1.99E+03 6.01E+00 1.24E+02 -6.30E+01 -4.59E+01 -2.01E+02 9.27E+01 6.57E
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******************** FIRST ORDER ***
******************** S MATRIX ***
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TH 1 TH 2 TH 3 OM11 OM12 OM13 OM22 OM23 OM33 SG
TH 1 7.83E+01
TH 2 -4.65E+00 7.65E-01
TH 3 -1.30E+03 6.44E+01 1.84E+05
OM11 -1.19E+01 2.62E+00 -2.31E+02 1.84E+01
OM12 1.43E+02 -2.86E+01 8.40E+02 -1.72E+02 2.01E+03
OM13 -2.67E+01 2.39E-01 3.80E+03 -1.97E+01 5.17E+01 1.29E+02
OM22 -1.46E+02 2.95E+01 9.00E+03 2.92E+02 -3.81E+03 1.89E+02 1.20E+04
OM23 4.44E+01 1.08E+01 -1.08E+04 8.49E+01 -7.65E+02 -2.93E+02 6.68E+02 1.12E+03
OM33 1.40E+01 -4.41E+00 -6.40E+03 3.47E+00 8.80E+01 -1.56E+02 -7.13E+02 2.95E+02 3.28E+02
SG11 2.04E+03 -3.98E+02 -4.14E+03 -1.17E+03 8.92E+03 1.80E+03 -3.83E+03 -1.06E+04 1.81E+03 4.20E
SG12 ......... ......... ......... ......... ......... ......... ......... ......... ......... ......
SG22 2.80E+02 -4.73E+01 -6.05E+04 -2.27E+01 6.71E+02 -1.11E+03 -3.49E+03 2.78E+03 2.36E+03 1.81E